MEDICAL weight loss

​We are all well aware of the obesity epidemic in this country.  More than two thirds of Americans are overweight and a third of Americans are obese. Obesity has now surpassed tobacco as the leading cause of preventable deaths. If losing weight was easy, it wouldn't be such a big problem and you probably wouldn't be reading this. But researchers are learning more about the appetite and obesity and some exciting new treatments are emerging. ​

THE HISTORY AND BASICS OF WEIGHT LOSS

The average adult male in 1960 weighed about 166 pounds. In 2018, the average adult male weighed about 200 pounds. The same increase has been seen in women. The average woman in 2018 weighed about 170 pounds. That is a 30 pound weight difference compared to the average woman in 1960.

 

Weight loss is a tricky subject.  On one hand it seems so simple.  Calories taken in verses calories burned off.  But if it were so easy, why do we have an obesity problem? It is much more complex than that, and science does not have all the answers. Let me try and give you a crash course on body physiology to help illustrate. First, some terms to familiarize yourself with:

  • Calorie:  A unit of heat measurement. Kilocalorie (Kcal), is a thousand calories. That is the actual number you see on               nutritional labels.  But instead of saying 250000 calories in a snickers bar, by convention we use Calorie, with a                   capital C, to equal kcalorie, or 250 Calories.

  • BMR:  Basal Metabolic Rate. The number of calories required to keep your body functioning at rest as if you were                       sleeping.

  • RMR:  Resting Metabolic Rate. The number of calories required to keep your body functioning at rest, like awake with               your eyes closed

  • BMI:  Body Mass Index is derived by a person’s weight, in kilograms, divided by height, in meters.

    • 25-29:  Overweight

    • 30-34:  Obese

    • 35-39:  Morbidly Obesity  

  • TDEE:  Total Daily Energy Expenditure 

The amount of energy you use every day, from waking up, showering, eating breakfast, going to work, doing chores around the house, maybe working out, and having sex represents your physical activity. Many people think this is where you would burn up most of your calories, but in fact, only about 15% of your daily caloric expenditure is utilized here. This is one of the reasons why exercise alone doesn’t help in weight loss. The overwhelming majority of calories, about 75%, are burned in your basal metabolic rate or (BMR). There is also the energy needed to digest your food, a process called thermogenesis. The combination of these three processes totaled up is the total daily energy expenditure or TDEE. Understanding this relationship, is paramount to understanding weight loss, weight gain, and weight neutrality.​​

KNOW YOUR BMR

Your basal metabolic rate (BMR) is the key to understanding weight loss. Unfortunately, it’s the one area researchers understand the least. BMR is the energy needed by your body to survive and for your lungs to breath, your heart to beat, your liver to cleanse, your brain to think, and your cells to divide and repair themselves. Every second of every hour of every day while awake or sleeping, your body is at work. So how do you find out what your BMR is? Type, BMR, in any internet search engine and you will get an array of explanations and calculators. The calculator will ask for your weight, height, age and sex. Some may ask for your body fat percentage, etc. These calculators are just a guess. The only way to determine your true BMR is to undergo an overnight study in a metabolic chamber, known as a whole room calorimeter. An excellent article was written by Jullia Belluz, for those who want to delve deeper into metabolic chamber testing. Problem is, there are not many of these facilities around. Most are for clinical research and not available to the general public. But there are other ways to more accurately determine your BMR.    The second most accurate way is indirect calorimetry. This is performed by laying down and relaxing while breathing into a handheld device for about 5 or 10 minutes. Any office that specializes in weight loss should offer this powerful tool to precisely assess your BMR.

There are multiple studies that show extreme differences in the calculated BMR, and a person’s actual BMR’s obtained through Metabolic chamber, or indirect calorimetry. Some have over-estimated by as much as 30%. Let me illustrate the importance of this with an everyday example. You are a 6 foot, 200 pound, 50-year-old man. You plug in your numbers from a website BMR calculator and get a BMR of about 1898 kcal per day. Is this correct? That’s the problem, because as noted above, there are many different formulas to calculate BMR. Which one should be used? 

 

          Harris-Benedict equation = 66 +( 6.2 × weight in pounds )+( 12.7 × height in inches ) - ( 6.76 ×                                                                       age in years)

          BMR =1,882

          Mifflin-St. Jeor = (10 x weight (kg)) + (6.25 x height (cm)) – (5 x age (years) + 5)       

          BMR = 1,780

          Katch-Mcardle formula = 370 + (21.6 x Lean Body Mass(kg)) {Lean Body Mass = (Weight(kg) x                                                                         (100-(Body Fat)))/100 }

          BMR = 1,925

The last formula is even more difficult to use because you must calculate your body fat percentage. Estimating your body fat is no easy task. There are 4 ways to determine body fat scientifically. The gold standard is hydro densitometry testing. This involves submersing your body in water and determining water displacement. Some scales can pass an electrical current to determine body fat, unfortunately, not very accurate. Skin calipers are another commonly used method. This method is very operator dependent. Again, more variability.

These three different formulas gave three different results. In our example, the BMR ranged from 1780 kcal to 1925 kcal. That’s a difference of about 145 Cal. That may not sound like a lot but, if you overestimated your BMR by 145 Cal a day, you could gain 1 lb in about 23 days. Therefore, one reason you may have not been losing weight could be the miscalculation of your BMR. 

EASIER TO DECREASE YOUR BMR HARDER TO INCREASE
 

Researchers don’t know why people have different metabolic rates. A couple of findings hold true. Genetics seem to play a major role. Men usually have higher BMR’s than women. BMR’s usually decrease with age, and about the only thing you can do to increase your metabolic rate is increase your lean muscle mass. Caffeine, green tea, chili peppers may increase your BMR slightly but not enough to be significant. Pills that claim to increase your metabolism are a waste of money and time.  

Although there is not a whole lot you can do to speed up your metabolism, slowing it down is easy. That is one reason why it is easier to gain weight than lose it. Fasting and Crash diets are one way the body slows down it’s BMR. This may have been an evolutionary safeguard. Thousands of years ago, when there were no fast food stores right around the corner, and the next meal could be days or weeks away, the body compensated for these lean times by slowing down its BMR to conserve calories thus preventing weight loss. Other things that can slow your BMR and make it easier to gain weight are sedentary lifestyles, low protein diets, lack of sleep, and increased sugar consumption. Since your BMR is where the large majority of calories are utilized, and is the cornerstone of any weight loss plan, it’s important to know as precisely as possible.

Thermogenesis, the digesting of food, also accounts for some burning of calories. Every time you eat, your body uses calories to digest and absorb your food. Some types of food require more calories for this process than others. For example, meals rich in protein use more calories than fatty meals. This process accounts for about 10% of your daily calorie requirement. So this, and your BMR, are pretty much out of your control and has nothing to do with your activity level.                  

 

DETERMINING PHYSICAL ACTIVITY LEVEL 
 

Now let’s discuss the third and final piece of your Total Daily Energy Expenditure which is your daily physical activity. TDEE is equal to the BMR plus thermogenesis plus daily physical activity. Of the TDEE, roughly 20% is used during your day to day physical activity. This is the most variable determination in daily calorie expenditure. Assessment of physical activity is highly subjective, with most people overestimating their daily activity level. Let’s face it, who wants to say sedentary lifestyle? The typical calculated calories burned in a day will depend on your weight, age and sex. The formulas will also ask to determine how physically “active” you are and range from sedentary, light, moderate, active to highly active. Using our 200 pound, 50 year old male, he would burn 1,976 Cal by using a sedentary activity level verses 3,114 Cal if he used a very active lifestyle for his activity level. If you decide to use a calorie calculator like this, it’s better to underestimate your activity level than overestimate it.  A better way would be to buy a accelerometer, such as Fitbit, which does a pretty good job estimating your daily activity level. It can, through proprietary algorhythms, roughly determine your daily calorie expenditure. They’ve done studies and it’s not perfect but probably the best you can get without using calorimetry or radioactive labeled water.

 

 

EXERCISE NOT THAT IMPORTANT IN WEIGHT LOSS

Exercise is important for many reasons, but the simple truth is, it accounts for very little in the big picture for weight loss. If you walk briskly at 4 miles an hour, for 30 minutes, depending on your weight, that 30 minute exercise session will be negated by an apple or 2 hard boiled eggs, or a protein bar or a glass of soda. The take home message is this, exercise for all the health benefits your body will derive from it, not to lose weight. The single most important factor, by far, to lose weight is your caloric intake.

 

So how many calories must you burn to lose weight? That depends on how quickly you want to lose it. A rough estimate to get you into the ball park is 500 Cal a day or 3,500 Cal per week to lose a pound a week. This was derived back in the 1950’s. The rational goes like this. A pound equals 454 grams. Fat contains 9 Cals per gram or 4,086 Cal, but most human body fat is made up of other substances and the fat composition is closer to about 85%, or about 3,500Cal. So, 500 Cal per day for 7 days, or 3,500 Cals per week. Recent research has shown this formula to hold true only in the early phases of diet and as time goes on the number of calories needed to lose a pound per week actually increase. This is why patients’ best results happen early on in their diets, often hitting the infamous plateau where each pound of weight loss becomes harder and harder as they lose more weight.

 

Counting calories is absolutely necessary! Anything you read that tells you differently is setting you up for failure. The biggest problem with counting calories is, most of us underestimate our daily caloric intake. Smart phones make it easier than ever to do this, but it will still be necessary to keep a calorie diary. Use this when you eat out to track everything you eat while you are away from home. You may think you can remember all the meals and snacks you eat while you are out, but you will forget. If you cook at home, you will also need to get a digital scale to weigh your portions and calculate calories. Counting calories is a pain, but it’s a good exercise for you to learn about portion sizes and to get a better understanding about what calories are in the foods you are consuming to fuel your body. After about a month or two, you won’t need your smart phone app or scale to calculate your daily total caloric intake.  You’ll know a majority of meals you’ll be eating, and their caloric values.    

 

Sometimes people need a little help or a “little jump start”, to get their diet headed in the right direction.  That’s where medical therapy can help. I personally, don’t like prescribing weight loss medication. I would much rather see patients lose weight with diet, exercise and life style changes, but giving the choice of obesity without meds or healthy weight with meds, I’ll pick the latter every time​​.

WEIGHT LOSS MEDICATIONS

Currently, there are 5 FDA approved weight loss drugs for long-term use and one for short-term weight loss (less than three months). I have prescribed all of these medications, and with some, have several years of patient feedback to reference. My comments that follow are generalizations. If you have tried one and it works for you, fantastic. Just because I didn’t see good results with the drug, doesn’t mean it won’t work for you. Everybody is different.

 

Phentermine (Adipex) is by far the most commonly prescribed and studied appetite suppressant. Patient polling shows Phentermine to be the favorite when compared to the other weight loss drugs. It is well tolerated, effective and relatively inexpensive. It is not recommended in patients with underlying heart disease, HTN, glaucoma, hyperthyroid disease, pregnancy and breast-feeding mothers. It works in the central nervous system to suppress appetite. You can expect to lose on average between 5-10% body weight. This is the drug I most commonly prescribe for short term weight loss and have had the most success with it. 

 

Xenical works by blocking the absorption of fat from your stomach. If you eat any fat, chances are high that you’ll have explosive orange diarrhea. The majority of my patients hated it.

 

Belviq  on the serotonin receptors in the brain. This medication is well tolerated but expensive. 60 tablets cost over $300.  Insurance does not usually cover it.

 

Qysmia is a combination of Phentermine and Topiramate. It is also an appetite suppressant. Multiple combinations make prescribing difficult. Over $200 for a monthly supply. This medication is effective but still double the cost of phentermine alone and no more effective.

 

Contrave is a combination of two medications, Naltrexone, which is used to treat alcohol and drug dependence, and Bupropion, which is used to treat depression. This is an appetite suppressant. It is expensive, roughly $250 per month.  I did not see significant weight loss in my patients.

Exenatide is a GLP-1 agonist peptide. iIt's branded name is Betta.   It's cousin, Liraglutide when used for weight loss is called Saxenda,  and Victoza when used for diabetes.  It is  a daily  sub cutaneous injection. So far, this is my second favorite weight loss drug. Many obese patients are pre-diabetic or diabetic, so this therapy kills two birds with one stone. It is covered by most insurance companies if you are pre-diabetic or diabetic, otherwise its quite expensive at about  $1,300 per month.​​ when prescribed from our peptide compounded therapy cost is about $300 a month.

Decreasing appetite

Phentermine

One of the most widely prescribed meds for weight loss, mostly because it works.  increases release of neurotransmitters which simulate metabolism and suppress appetite. Phentermine isa “sympathomimetic” because it simulates the release and inhibition of certain neurotransmitters in your brain,

specifically dopamine and norepinephrine. Essentially it tricks your mind into feeling full

37.5mg $64 month supply

(Initial consultation fee $75)

Oxytocin

for weight management has been shown to decrease overall weight through reduced caloric consumption in both animal and human models. Data suggests this is done by modulating the activation of hedonic food motivation pathways. The ventral tegmental area (VTA) is one part of this pathway and the origin of dopaminergic bodies. The VTA also has oxytocin receptors, and it is believed that saturating these receptors with exogenous oxytocin administration is what leads to the downstream effect of decreased food desire

20 IU nasal spray $125

 

 

Amlexanox

Amlexanox is an anti-inflammatory and anti-allergic compound which has traditionally been used to treat ulcers by reducing healing time and pain. It has multiple mechanisms of action such as inhibiting inflammation by inhibiting therelease of histamine and leukotrienes. It has been shown to selectively inhibit TBK1 and IKK-ε, producing reversible weight loss and improved insulin sensitivity. It is through this mechanism that it has produced substantial results in terms of reducing HbA1C levels and increasing insulin sensitivity. This is a relatively novel drug that you will soon be hearing a lot about. 

PROTOCOL:

Content & Potency: 40mg capsules provided in a quantity of 90.

Suggested dosage: Take one capsule by mouth 3 times daily.

90 capsules 1 month supply $75

Increasing utilization of fat

Exenatide is a GLP-1 agonist peptide. iIt's branded name is Bydureon. Although used for diabetes, it is also used for weight loss.  It is  a daily sub cutaneous injection. So far, this is my second favorite weight loss drug. Many obese patients are pre-diabetic or diabetic, so this therapy kills two birds with one stone. It is covered by most insurance companies if you are pre-diabetic or diabetic, otherwise its quite expensive at about $800 per month.​​ when prescribed from our peptide compounded therapy cost is about $170 a month.

MIC B12 L-Carnitine 25/50/50/1/50mg/ml 10mL injectable

Methionine, an essential amino acid, helps the liver breakdown fats, lowers cholesterol, relieves fatigue and helps

allergies by lowering histamine release. Inositol, a B vitamin, helps the breakdown of fats, lowers cholesterol, and helps control mood and appetite. Choline, an essential nutrient, helps the liver breakdown fats and excrete toxins. B12, a vitamin that boosts energy and overall metabolic rate, assists inthe burning of stored body fat, helps detox, and helps regulate sleep, mood, and appetite. The addition of L-Carnitine will assist in converting body fat to fuel and elevate certain enzymes needed to metabolize sugars, starches, and other carbohydrates. It is used to facilitate fatty acid oxidation, aiding in the reduction of body fat, both systemically and site specifically.

IV infusion $175

(must call and schedule for IV infusion)

OUR APPROACH TO WEIGHT LOSS

We start with a  body composition analyses using bioelectrical Impedance Analysis technology. Our body composition monitors can measure your weight, body fat percentage, body water percentage, muscle mass, basal metabolic rate (BMR),  bone mass, and visceral fat. Once we assess your BMR, we determine a reasonable weight loss diet that is custom tailored for you, no one else.  We can build a diet plan to help you lose weight conservatively (1/2 pound a week), or a more aggressive weight loss plan losing 2 pounds per week. We promote realistic lifestyle changes. When appropriate, we offer medical therapy, as discussed above which may also include weight loss peptide injections, to help you see quicker results. In some cases, the first month’s therapy is included with initial

consultation fee.

Initial consultation fee is $75 which includes:

  • Body composition analysis

  • Basal Metabolic assessment

  • Personalized diet plan

  • concierge service 

  • Telemedicine consult,  save time, avoid office waiting and driving.  All meds delivered to your home.

Remember, Losing weight is not, easy that's why it is a national epidemic.  These meds can help "jump start" your weight loss, but in the end it is about a lifestyle change.  We would enjoy talking with you and answer any questions you may have. We look forward to helping you lose weight and keeping it off. Call us for an appointment at 412-248-7777.

Contact

Invigorate Med Spa

8199 McKnight Rd, Pittsburgh, PA 15237

 

Office: (412) 248.7777​​

Fax: (412) 369.2286

info@invigoratemedspa.com

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